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Warning signs include: Dizziness upon standing Decreased urination or dark urine Dry mouth and increased thirst Muscle weakness or cramping Other Concerning Symptoms Immediate medical attention is warranted if fatigue occurs with: Severe abdominal pain (may indicate pancreatitis) Right upper quadrant pain, fever, or yellowing of skin/eyes (signs of gallbladder disease) Persistent vomiting preventing fluid intake Visual changes or severe headache (especially in patients with diabetes and retinopathy) Chest pain or shortness of breath Signs of allergic reaction (rash, swelling, difficulty breathing) The American Diabetes Association Standards of Care recommend regular monitoring of patients on GLP-1 receptor agonists, including assessment of tolerability, glycemic control, weight changes, and overall well-being

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doi: 10.1053/j.gastro.2021.12.282 24 CowardSClementFBenchimolEIBernsteinCNAvina-ZubietaJABittonAet al