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T1D and CD T1D and CD have a complex mechanism (Shalimova et al., 2019) but share a disturbance in insulin secretion in blood and sensitivity in insulin receptor (IR) to activate oxidative stress (Newsholme et al., 2016) and inflammatory cascade that causes mitochondrial damage, especially in neuronal and dendritic processes in AD (Khan & Hegde, 2020)
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