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As noted previously, increasing age is linked to reduced GSH levels (Drge, 2002a,b), which can be the result of extensive GSH oxidation and/or reduced pool of cell thiols, and cysteine (whey protein) administration enhances GSH levels and increases longevity (Bounous et al., 1989
These findings are significant for aging research because melatonin decline is associated with increased oxidative stress and circadian disruption in studied populations
Mercury, in particular, depletes glutathione reserves and weakens glutathione-dependent enzymes
Acknowledgments This work was supported in part by the Japan Study Group of NAFLD (JSG-NAFLD, Kyoto, Japan)
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