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If sterile technique was compromised, bacterial growth may be present even in a clear solution, especially in the early stages before the colony is large enough to cause visible turbidity

Dose interruptions or reductions may be required for side effects (e.g., high hemoglobin, hypertension, bone pain)

Mechanisms relevant to psoriasis: Reduces NF-B activity (a key inflammatory pathway in psoriasis) Decreases pro-inflammatory cytokines Promotes collagen synthesis and skin remodeling Activates wound healing gene expression Anti-oxidant properties reduce oxidative stress in lesions Research highlight: GHK-Cu has been shown to reset gene expression patterns associated with aging and inflammation

The Cochrane Risk of Bias tool (RoB2) was used to assess the risk of bias in the studies (Fig