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Over a 4.5-year period, an estimated 847,598 MACE would occur in the absence of treatment with oral semaglutide, compared with 728,934 events with treatmentcorresponding to 118,664 events potentially prevented (14%), with a number needed to treat (NNT) of 55 (Table 2)
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In the STEP 1 trial 23 , the mean change in body weight from baseline to 68 weeks was 14.9%, compared with 2.4% with placebo
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