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Yamamoto, K., Senba, E., Matsunaga, T
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It may be that the main impact of physiologic insulin regimens and insulin glargine, in particular, is that the separation of prandial and basal components improves our understanding of insulin use, simplifies dosing adjustments, and allows patients more flexibility in meal timing
More serious but less common side effects to watch for at this dose include acute pancreatitis (symptoms: severe abdominal pain radiating to the back, nausea, vomiting), gallbladder problems (symptoms: sudden pain in the upper right abdomen, fever, jaundice), and significant hypoglycemia if combined with certain diabetes medications
