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and inter alia, further down-regulates insulin function and thereby exacerbates Metabolic Syndrome
doi:10.1093/toxsci/kfm165
Darkness of the skin depends on the concentration of skin pigment Melanin synthesized in the basal level of epidermis
Formulations should incorporate stabilizing technologies (such as ethosomes or encapsulation systems) to reduce irritation potential while enhancing permeation without overwhelming the skin barrier
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