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Evaluation of intact proinsulin levels reveals significant decreases with tirzepatide at 5, 10, and 15 mg doses, indicating potential positive changes in insulin processing.Furthermore, tirzepatide therapy dramatically lowers glucose-adjusted glucagon levels, emphasizing improvements in glucose regulation, beta-cell activity, insulin processing, and reduced glucagon levels [74]

doi: 10.1371/journal.pone.0172239

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Overall, these results suggest that GLP-1 medications like semaglutide may influence both eating and substance use behaviors, offering potential benefits for individuals with alcohol use disorder