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Patients with early hereditary optic nerve atrophy, cyanocobalmin hypersensitivity, and those who are pregnant
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High activity of TGF- [187, 188], histone deacetylase 8 (HDAC8) [189], p21-activated kinase 4 (PAK4) [190, 191], protein phosphatase 2 A (PP2A) [192], cyclin-dependent kinase 4/6 (CDK4/6) [160, 193], orphan GPR182 [194], and WNT/-catenin [195,196,197], as well as loss of phosphatase and tensin homolog (PTEN) [198,199,200], hamper CD8 + T-cell infiltration and promote their exclusion
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