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Under the rich nutrient state, mTORC1 binds to the ULK1 complex and inhibits the initiation of autophagy through inhibitory phosphorylation of ULK1 at Ser-757 (Kim et al., 2011
Potential reproductive or systemic consequences have not been well studied, but theoretical risks include changes to hormonal feedback, timing of ovulation, and unintended effects on sperm or embryo development
Even so, there are some clear advantages to the morning time
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