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Am J Physiol Endocrinol Metab (2000) 279(1):E8894
There are also indications of potential neuroprotective effects on cerebral glucose metabolism and modest increases in blood-brain glucose transport capacity in the brain measured using 18F-FDG PET [16]
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SS-31 (elamipretide) , a mitochondria-targeted peptide that stabilizes cardiolipin to support energy production, became the first FDA-approved mitochondrial therapeutic in 2025, though only for the rare Barth syndrome, with the brain rationale still mechanistic and no cognitive trials
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