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Protective effect of sitagliptin against renal ischemia reperfusion injury in rats

2019 Apr 16 last updated 2021 Mar 25: Accessed 2021 Mar 25

Mechanistically, activation of GLP-1R by GLP-1 or exenatide phosphorylates STAT3, which drives human monocyte-derived macrophages to develop an M2 phenotype marked by increased expression of CD163, CD204, and IL-10 [86]

Testing can reveal whether a patient genetically favors dopamine-driven approaches (bupropion's strength) or gut-hormone-driven approaches (semaglutide's mechanism), helping clinicians design truly personalized dual therapy