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In 2023, the FDA launched an investigation after GLP-1 agonist users started reporting thoughts of suicide as of January 2024, it hadnt found anything to confirm the connection, but it also said it couldnt yet rule it out, meaning its possible the drugs could cause mental health issues for some people, rather than treating or preventing them
This reprogramming is driven by alterations in glycolytic enzymes regulated by the UPS
In addition, the inclusion of patients with different diagnostic criteria may introduce clinical heterogeneity, and evidence users should consider this
This different molecular mechanism would allow to overcome cell resistance against platinum agents
