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About 4% of patients discontinue tirzepatide due to intolerable side effects
Wegovys full approval for this indication is dependent on additional clinical trial data confirming its safety and efficacy
Broadhouse et al demonstrated a clear protection of the left hippocampus with 6 months of high-intensity RT (3 sets of 8 repetitions at 80% 1RM, two or three times per week) compared to shaman effect that persisted 1-year post-intervention in the 200 older adults studied (Hainmueller and Bartos, 2020), and hippocampal synaptic relay ( The benefits of RT on hippocampal subfields are further supported by recent work from Vints et al, demonstrating that even 12 weeks of progressive RT peaking at 85% of 1RM was sufficient in improving CA1, CA4, subiculum, and dentate gyrus volume in 70 older men and women (Vints et al., 2024)
Agrawal R, Reno CM, Sharma S, Christensen C, Huang Y, Fisher SJ
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