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In an environment characterized by oxidative stress and mitochondrial dysfunction, the presence of oxLDL further increases the secretion of proinflammatory cytokines (e.g., tumor necrosis factor , interleukin [IL]-6 and IL-1) and the expression of adhesion molecules (including vascular cell adhesion protein [VCAM]-1, monocyte chemoattractant protein [MCP]-1, intercellular adhesion molecule [ICAM]-1 and E-selectin) by monocytes and macrophages ( GLP-1 receptor stimulation appears to attenuate these processes in preclinical models and human studies in various ways

Think of it as a cellular security guard that identifies unstable molecules, known as free radicals, and neutralizes them before they can harm your DNA or cellular structures

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For more detailed information about the cellular uptake of exosomes, the reader is referred to the review of Mathieu et al