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Regarding cardiovascular parameters , clinical trials have consistently observed modest increases in resting heart rate with GLP-1 receptor agonists, typically in the range of 24 beats per minute
GHRH-analog and secretagogue schedules commonly run 812 weeks on, followed by 4 weeks off , allowing receptor sensitivity and the IGF-1 axis to reset before another cycle
Sawhney MS, Prakash C, Lustman PJ et al
Safety Concerns and Liability Issues Like all pharmaceuticals, GLP-1 medications carry inherent safety challenges, including the risk of unanticipated adverse side effects
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