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This broad receptor distribution underlies the pleiotropic research profile of GLP-1 from appetite and reward behaviour regulation in the central nervous system, to cardioprotective effects in cardiac tissue, to anti-inflammatory and immunomodulatory activity in immune cell models
Intriguingly, pharmacological GIPR agonism combined with GLP-1R agonism also involves CNS-GIPR signaling in the control of satiety pathways (15, 16), suggesting rewiring of incretin signaling in obesity
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