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They are often described as sudden feelings of warmth, usually in the upper body, that can cause sweating and a flushed appearance

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Lower cost and injection burden while still capturing most of the synergy benefit around glucose metabolism

Side Effects Comparison Both medications share similar side effect profiles, mainly affecting your digestive system: Nausea (the most common) Vomiting Diarrhea Constipation Stomach pain According to meta-analysis data, adverse events occurred more frequently with retatrutide (risk ratio: 4.10) compared to tirzepatide (risk ratio: 2.78)