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The meta-analysis of the ELIXA, LEADER, SUSTAIN-6, EXSCEL, Harmony, PIONEER 6, REWIND and AMPLITUDE-O trials shows that the extent of HbA 1c reduction may serve as a proxy for the renal benefits of GLP-1RA therapy
( A and B ) Intracellular cAMP accumulation measured by enzymatic immunoassay in lysates from ( A ) caSMCs and ( B ) mouse and human caECs treated for 10 minutes with 100 nM each of GLP-1(2836), scrambled control, IPE, forskolin, or PBS control ( n = 3/treatment, each in triplicate)
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