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The maintenance phase requires as much intentional engagement with nutrition, activity, sleep, and medication adherence as the weight loss phase did. Part of the reason is biological

van Diepen S (2018): Norepinephrine as a First-Line Inopressor in Cardiogenic Shock: Oversimplification or Best Practice

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We also emphasize both preclinical and clinical studies identifying how agonists to these receptors transduce their metabolic actions