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If symptoms remain significant after four weeks with dietary adjustments in place, discuss a slower titration or dose reduction with a healthcare provider
Ordinarily, people start at lower doses and work up over time to the therapeutic amount so their bodies can adjust
"Tirzepatide versus Insulin Glargine in Type 2 Diabetes and Increased Cardiovascular Risk (SURPASS-4): A Randomised, Open-Label, Parallel-Group, Multicentre, Phase 3 Trial." The Lancet, 2021, 398(10313), 1811-1824
For patients with established IBD, the gastrointestinal side effects of full-dose GLP-1 therapy can be problematic
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