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As we have documented the tolerability of L-PAM+BSO when supported by autologous stem cell infusion in heavily pretreated relapsed and/or refractory neuroblastoma patients (NANT phase I study, NCT00005835, www.clinicaltrials.gov), using myeloablative L-PAM+BSO is clinically feasible
High Hcy levels are often caused by low intake or poor metabolism of vitamins B6, B9, and B12 (found in green vegetables and citrus) or by gene mutations that affect Hcy breakdown
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