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For 2 mg dose: 2 / 4 x 100 = 50 units Doses per vial at 2 mg daily: All multi-dose vials sit well within the 28-day reconstituted shelf life at the standard 2 mg daily dose

Conservative initial dosing allows researchers to assess individual response patterns while minimizing the risk of adverse reactions

Main pathway: G-actin sequestration Native T4 binds monomeric G-actin with a dissociation constant (KD) of approximately 1 M, controlling the pool of free actin available for polymerization into F-actin (actin filaments)

Recent Phase 1 clinical trial results confirmed its tolerability and pharmacologically active exposure levels in healthy participants (AUCinf 13850.7 ngh/mL and doses up to 480 mg)