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the label states its unknown whether the risk applies to humans, and it lists contraindications including personal/family history of medullary thyroid carcinoma (MTC) or MEN2 (FDA label (PDF))
For comparison, tirzepatide before and after results in men show similar or greater reductions over comparable timeframes, as the dual-agonist mechanism targets both GLP-1 and GIP receptors simultaneously
If you experience gastrointestinal discomfort or indigestion, do not take on an empty stomach
The key during the first 2 weeks at 12mg is managing the GI adjustment
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