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doi: 10.6065/apem.2017.22.3.145 106 WoltersTLCNeteaMGRiksenNPHermusARMMNetea-MaierRT
Since the progression to invasive PDAC is believed to take more than a decade, the follow-up periods in many cohort studies and randomized controlled trials (where it is typically 12 years) are insufficient to understand the long-term effects
The underlying mechanism appears to be associated with epigenetic changes, specifically involving the deacetylation of histone H3 within the Treg cells (57)
Smaller compounds such as catechins, caffeic acid or taxifolin can be absorbed in the small intestine and are usually present in blood samples approximately 0.52 h after ingestion (50, 52, 53)
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