The injectable form was placed on the FDA's Category 2 bulk drug substances list in 2023, restricting compounding pharmacies from preparing it under Section 503A
But the agency released a public advisory on unauthorized injectable peptides in April warning that these products can be dangerous and cause hormonal imbalance, mood swings, blood sugar imbalance, liver or kidney damage, blood clots, and growth of cancerous tumours. The advisory encourages Canadians to only buy prescription drugs from licensed pharmacies and to check for a drugs eight-digit drug identification number to ensure its legal.
Using the same FRET-based assay, we compared the activity of X(PC) to that of wild-type BoNT/X protease on its native substrate VAMP1 ( K m = 6.93 M, k cat = 3.52 s 1 , k cat / K m = 0.508 s 1 M 1
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