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Class B GPCRs, includ-ing the GLP-1R, are activated by endogenous peptide hormones, and the development of small-molecule agonists of these receptors has proven to be particularly challenging
In this study, a 2-month KD in middle-aged female mice resulted in elevated HB in serum, the liver, the gastrocnemius muscle, and the hippocampal and cortex brain regions, as well as higher concentrations of hepatic glycerol, consistent with the ketogenic diet phenotype previously described [29]
Antioxidants, like glutathione, neutralize free radicals to prevent them from causing cellular and DNA damage
doi: 10.1152/physrev.00013.2014 78 HopeDCDVincentMLTanTMM
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