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A 2025 meta-analysis found that weight decreased by about 0.04 kg per day, while fat-free mass decreased by about 0.007 kg per day

The new 7.2 mg dose added one notable signal: about 22% of patients reported dysesthesia (tingling or altered skin sensation)

Sandler 1990

Since NAD+ is closely linked to vitamin B3, these supplements are generally safer than the botanical blends in nootropics, though they arent necessarily less expensive, depending on the brand you choose