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Melanocortin-4 Receptor Agonists Melanocortin receptors such as the melanocortin-4 receptor (MC4R) are stimulated by POMC-derived melanocortin peptides within the hypothalamus to suppress appetite
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On the other hand, in case of excessive distress, cells are exposed to high levels of ROS which can cause neuroinflammation, damage to the blood-brain barrier (BBB) and impairment to astrocyte crosstalk leading to ASD (Russo et al., 2018)
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