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Cell Metab 27(2):450460
10.1016/j.parkreldis.2016.03.018 134 ParkJ
Some patients experience a paradoxical energy boost in the evenings during early treatmenta phenomenon sometimes called the 'tirzepatide rebound.' This occurs because your body is burning stored energy more efficiently, leading to increased dopamine and norepinephrine activity late in the day
The results may be reconcilable by the existence of distinct Gipr -expressing target cell populations with different physiological roles and responsiveness
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