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According to the safety communication, patients at particular risk for developing Torsade include: Patients with underlying heart conditions, such as congenital long QT syndrome Patient who are predisposed to low levels of potassium and magnesium in the blood Patients taking other medications that lead to QT prolongation Clinical Studies: Zofrans Link to Heart Rhythm Problems The FDA released another Drug Safety Communication in June 2012, informing health care professionals and the public that preliminary results from a clinical study suggested that a 32 mg, single intravenous dose of Zofran may cause QT interval prolongation

Our findings echo this pattern, with improvements observed across all domains but not always reaching statistical significance for mental aspects of HRQoL outcomes