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Three specific conditions qualify for Tier 2 (BMI 30 or higher): (1) heart failure with preserved ejection fraction (HFpEF), (2) uncontrolled hypertension despite treatment with two or more antihypertensive medications (systolic over 140 or diastolic over 90), and (3) chronic kidney disease stage 3a or higher (estimated GFR below 60)

Biochem Pharmacol (1989) 38:32730.10.1016/0006-2952(89)90044-0 164 ClemmensenCSmajilovicSWellendorphPBrauner-OsborneH

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