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Its also possible that GLP-1s directly reduce the absorption of hormonal contraceptives by delaying gastric emptying, as stated on Mounjaros drug label
That molecule takes three critical actions
The nasal spray delivery format, however, is the true weak link in this chain
L-cells, the specialized cells lining our digestive tract that produce appetite-suppressing hormones like GLP-1, have receptors on their surface that respond to carbohydrates, proteins, and fatsas well as detect bitter compounds, like the quinine in tonic water that Ive talked about before, as well as pungent molecules, as I detailed in my video on spices
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