Persistent vomiting or diarrhoea can lead to dehydration, which in turn may increase the risk of acute kidney injury a class-relevant concern also noted in the Summary of Product Characteristics (SmPC) for approved GLP-1 receptor agonists such as semaglutide
Acetylcholine is known to be critical for cognitive processes (Hasselmo 2006), and caffeine has been shown to enhance acetylcholine release (Carter et al
Dehydration, caloric restriction, and electrolyte shifts are named as common contributors, which is why it stresses hydration, electrolytes, and consistent meal timing
By interacting with GIP , GLP-1 , and glucagon receptors, it helps regulate appetite, glucose levels, and energy use