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In STZ-induced diabetic mice, proximal tubule specific knockout of phosphofurin acidic cluster sorting protein 2 (PACS-2) gene severely impaired reticulophagy of tubular cells and aggravates kidney injury

Additionally, in wild-type mice that overexpressed hHPN WT , there was a significant reduction in Cx32 expression, i.e., approximately 50 9% compared with both the AAV-hHPN RS and the vector-control (AAV-EGFP) groups (Fig

Moreover, aescin has been scarcely investigated in this context

Weinstein G, ODonnell A, Davis-Plourde K, Zelber-Sagi S, Ghosh S, DeCarli CS, Thibault EG, Sperling RA, Johnson KA, Beiser AS, Seshadri S