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A 2019 Phase 2 dose-escalation study compared three different titration algorithms over 12 weeks and found that slower escalation reduced gastrointestinal events without losing efficacy at the target maintenance dose
From a pharmacokinetic perspective, studies indicate no evidence that the combination of Vitamins B1, B6, and B12 adversely affects the pharmacokinetics of each individual vitamin
OPRAH: Yeah
But an association seen in groups of patients is a long way from a prediction about any one person, and the authors note that the causes of a high B12 are multiple and its consequences not clearly established
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