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It is important to understand that the key players evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake

143,144 The mutated IDH1 and IDH2 proteins are endowed with a novel ability to catalyze the reduction of -KG to generate a rare metabolite, 2-hydroxyglutarate (2-HG), while consuming NADPH

doi.org/10.1007/s00109-016-1488-y Vasireddi, N., et al

Answers to these questions may help guide obesity treatment, but may also inform future areas of research as we learn more about the beneficial effects of GLP-1 receptor agonists such as semaglutide, Ortiz-Pujols said