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Serious but Rare Risks GLP-1 medications can aggravate or trigger severe pancreatic inflammation in some patients. Both oral and injectable GLP-1 medications may cause gallbladder disease, and in rare cases involving patients with relevant risk factors, there have been associations with thyroid changes observed in animal studies. A serious allergic reaction is possible but uncommon
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In the Increlex (native mecasermin) FDA-approved program, hypoglycemia was reported in 42% of subjects, with five subjects experiencing severe episodes requiring assistance and four experiencing seizures or loss of consciousness
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