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& Sibille, E
More stimulation does not equal better outcomes
The enzyme dipeptidyl peptidase-4 (DPP-4) rapidly inactivates GLP-1 by removing two N-terminal amino acids and an intact N-terminal is needed to bind to the GLP-1 receptor [35]
A 2021 study identified a putative beta-arrestin "superagonist" of the ghrelin receptor, showing that biased agonism at this receptor could produce functionally distinct outcomes depending on which signaling pathway is preferentially activated
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