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A complex sequence of reactions begins with activation of toll-like receptor 4 (TLR4), a receptor for endotoxins, which leads to accumulation of the cyclooxygenase-2-derived lipoxin precursor 15-HETE esterified to the membrane phospholipids, especially phosphatidylinositol, a reaction that can be enhanced by aspirin treatment

10.3390/nu5093424 80 GapperN

Fernndez-Checa, Liver Unit, Hospital Clnic, Centre Esther Koplowitz, Institut dInvestigacions Biomdiques August Pi i Sunyer (IDIBAPS)Centro de Investigacin Biomdica en Red de Enfermedades Hepticas y Digestivas (CIBERehd), Planta Cuarta, C/Rossell 149, Barcelona 08036, Spain e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a Section of the journal Frontiers in Pharmacology