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Given the established role of norepinephrine as a key in stress responses, modulating excitatory and inhibitory signals, especially in the amygdala and prefrontal cortex, affecting anxiety and defensive behaviors 85,86,87 , and the knowledge that chronic stress reduces norepinephrine and locus coeruleus activity, highlighting norepinephrine reuptake inhibitors role in treatment 88,89 , our findings suggest that PC-12 Adh cells treated with norepinephrine could offer insights into cellular stress mechanisms, replicating neurochemical and behavioral responses seen in vivo

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This variant leads to an amino acid substitution that may impair enzyme activity and alter local T3 availability, particularly in the brain and pituitary