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All authors commented on and critically revised the manuscript

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Tom M,Murdoch PDS,Durn RV

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Strong evidence should include improved recipient-cell bioenergetics, tracking of donor-specific mitochondrial DNA or proteins, ultrastructural or high-resolution live-cell confirmation, loss-of-function experiments, and functional rescue [31,32,33,34,35]

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For men, testosterone's anabolic effects on skeletal muscle create an environment in which MOTS-c's enhancement of glucose uptake and mitochondrial biogenesis may be particularly well expressed, making MOTS-c a natural companion to testosterone optimization programs

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