melanotic schwannoma spine At MRI, spinal is usually located along a spinal nerve root, The presence of paramagnetic free radicals in melanin creates characteristic T1 hyperintensity and T2 hypointensity, any ddx? #radiology #radiologist # Psammomatous Melanotic Schwannoma - DoveMed

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Neuroprotective effects of glucagon-like peptide-1 (GLP-1) analogues in epilepsy and associated comorbidities

GAA is an aldosterone-type triterpenoid derived from Ganoderma lucidum, known for its antioxidant, anti-inflammatory, antidepressant, and anticancer properties ( In vitro experiments confirmed that A 25-35 treatment significantly inhibited the activation of the NRF2/SLC7A11/GPX4 signaling pathway in HT22 cells, upregulated the expression of Fe 2+ , TFR1, ACSL4, MDA, and GSSG, and decreased the expression of FTH1, SOD, and GSH, as well as the GSH/GSSG ratio, resulting in dysregulated neuronal iron metabolism, impaired amino acid antioxidant systems, mitochondrial dysfunction, and ferroptosis, which ultimately promoted neuronal injury