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Most of the mutations in SLC22A5 are missenses mutations but nonsense, splice site, and deletion/insertion mutations have also been identified
For patients whose clinical situation requires moderate rather than maximal weight loss, such as those with early-stage metabolic dysfunction where 10-12% weight loss is sufficient to normalize metabolic parameters, orforglipron's efficacy profile may be adequate and its oral convenience advantageous
"All of this information suggests that these agents should be used with care and only among patients at greatest risk of poor health or obesity-related complications that have been appropriately counselled about their risks," Ward said
August 2020
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