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To avoid hyperglycemia and hyperinsulinemia due to IGF-1R antibodies, the I-SPY 2 trial has used ganitumab in combination with the antihyperglycemic agent metformin (NCT01042379)
Usually 34 weeks with consistent use
It is a synthetic 15-amino acid pentadecapeptide derived from a partial sequence of the human gastric protective protein
An Axiovert 200M or a Zeiss Observer Z.1, both equipped with a large incubation chamber (37 C), 5% CO 2 and humidity control were used for all of the live imaging experiments
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