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doi: 10.3389/fmed.2023.1124275 Received 14 December 2022 Accepted 27 February 2023 Published 22 March 2023 Volume 10 - 2023 Edited by Ana Sandoval-Rodriguez, University of Guadalajara, Mexico Reviewed by Angelo Armandi, University of Turin, Italy

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For instance, if the activity of superoxide scavenging by SOD2 exceeds the capacity to remove the H2O2 generated, this oxidant can cause oxidative damage or be converted to other ROS