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Inhibitors do not convert TGR into an NADPH oxidase Several covalent inhibitors of TGR are electrophilic compounds reacting with the Sec residue at the C-terminus, which induce a transition in the enzyme from an antioxidant to a pro-oxidant with increased NADPH consumption 20,45
Markedly elevated concentrations of total homocysteine (tHcy) in blood are the biochemical hallmark of cobalamin-related remethylation disorders
doi: 10.3390/v12010066 59 Otulak-KozieK.KozieE.PrzewodowskiW.CiackaK.PrzewodowskaA
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