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The 200 to 500mcg figures widely used across clinic and community contexts are derived from animal extrapolation and accumulated self-experimentation, not controlled human trials
It is the only method that provides tissue for pathological diagnosis, making it essential for atypical moles
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A common guideline is not to exceed ~4.5 mg/kg of body weight (about 300 mg total in an average adult) when given without epinephrine
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