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REDEFINE 2 (Phase 3a, NEJM 2025) Davies et al., n=1,206, 68 weeks, T2D + BMI 27
A 2018 review in the International Journal of Molecular Sciences compiled transcriptome-profiling data showing thousands of human genes flagged as up- or down-regulated under GHK-Cu exposure across multiple cell-type studies, framing the compound's pleiotropy at the regulatory-network level (PMID 29986520)
This makes it extraordinarily sensitive to changes in hormonal signaling
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