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This article was reviewed and minor updates were made in February 2026.
If neurological symptoms are present, intramuscular hydroxocobalamin treatment should be started promptly and must not be delayed whilst awaiting all test results
Through this mechanism, it has been shown in experimental models to enhance PGC-1 expression, increase mitochondrial density, and improve fatty acid oxidation
When B12 levels are too low, the nerves can become damaged, leading to sensations like numbness, tingling, or a pins and needles feeling in the hands, feet, or legs
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